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However, the molecular mechanisms underlying this switch remain poorly understood. However, the mechanisms underlying this switch are still not well established. On that basis, a eukaryotic expression vector of pcDNA3. Surviving single colonies were then picked and amplified.
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Despite impressive clinical success, cancer immunotherapy remains ineffective in many patients due to the establishment of tumor resistance, largely dependent on the nature of tumor microenvironment. There are several cellular and molecular mechanisms at play, and the goal is to identify those that are clinically significant. Among the hematopoietic-derived cells, monocytes are endowed with high plasticity, responsible for their pro- and anti-tumoral function. Indeed, monocytes are involved in several cancer-associated processes such as immune-tolerance, metastatic spread, neoangiogenesis, and chemotherapy resistance; on the other hand, by presenting cancer-associated antigens, they can also promote and sustain anti-tumoral T cell response.
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Liff is a village in Angus, Scotland , situated 4. Surrounded by farmland, it has been described as 'haunted by wood pigeons and the scent of wild garlic' and having a 'wonderful view over the firth [of Tay]'. Further east lie Camperdown House and Park.
HE'S one of the most famous Scots alive, internationally recognised for his distinctive and dashing looks and smooth accent. Today, Sir Sean Connery celebrates his 80th birthday, a landmark year in an astonishing life. But how well do we really know Edinburgh's most famous living son? Here, we look at 80 facts - some well known, some less so - that have helped mould his remarkable life.
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